Most preventive treatment of all cases of bronchial asthma except an uncomplicated form of the disease recommends the use of inhaled glucocorticoids. Since the introduction of glucocorticoids in 1972, the drugs of this group remain highly relevant due to its low cost, availability and safety.
About one out of five patients with bronchial asthma is treated with glucocorticoids, generally recommended for chronic, acute and complicated cases of asthma. Prednisone is famous glucocorticoid known for lower risk of side effects and fewer complications. The doctors prescribe it often in severe cases because it is a fast-acting glucocorticoid beta-2 agonist that can be taken once a day or three times a week.
Prednisone is available in the form of tablets of 5 mg for oral use or in the form of injections of 30 mg for intravenous and intramuscular use.
The treatment can start with high doses of the drug and eventually go down to lower dose following the so-called “step down” approach. The initial high dosage is given to combat the disease as quickly as possible in the following cases:
- To reduce seizures;
- To treat acute condition or complication;
- To improve function of respiratory system;
- To minimize side affect in the case of adverse reaction.
It has been clinically proven that the early treatment with a glucocorticoid drug delivers a significant improvement of the condition. Prednisone prevents and blocks inflammatory process, as well as deteriorative changes of the respiratory tract. Prednisone is especially useful in treating children with bronchial asthma.
As a medicine, Prednisone has anti-inflammatory and anti-allergic effects. Also, the drug has an immunosuppressive effect increasing the sensitivity of beta 2-adrenergic receptors. As Prednisone interacts with specific receptors of the cytoplasm, it helps to start the process protein formation. For obstructive diseases of the respiratory tract in general and bronchial asthma in particular, Prednisone is effective mainly due to the reduction of inflammatory processes.
- Eliminates or reduces the edema of the mucous membranes.
- Creates immune complexes in the bronchial mucosa.
- Prevents erosion and desquamation of the mucosa.
- Reduces the risk of scar tissue formation.
- Reduces risk of side effects for connective tissue.
It is recommended that the first course of therapy does not exceed 16 days. The doctors prescribe patients to start treatment with 5 or 6 mg per a day, and when the condition improves, the dosage is reduced to 3 mg. The high daily dosage of 1,5 or 2,5 tablets can be recommended only once. It can be recommended taking a double daily dosage every other day in severe cases. The dosage and duration are defined and prescribed individually in each instance. You should always consult a doctor before taking medicine.
It is important for patients to follow the explicit instructions given to him by the physician about the administration, the duration, the dosages of the course of treatment. The Prednisone is crucial in treating of bronchial asthma, but you should never take it without doctor’s recommendation. If the physician prescribed Prednisone, you should carefully read the instructions first and follow the recommendations diligently to achieve desired results and to improve your health.