The contraindications for the use of Prednisone are:
- serious infections
- hypersensitivity to medicine
It should not be used under the following conditions:
- HBsAg-positive chronic active hepatitis
- 2 months before and 14 days after prophylactic vaccination
- herpes simplex infection
- herpes zoster infection
- other viral infections
Prednisone may only be used with extra caution and only after consulting your doctor in the following situations:
- ulcers in the stomach and duodenum
- acute and chronic bacterial infections
- fungal infections affecting the skin and internal organs
- infections caused by parasites
- unstable hypertension
- neuropsychiatric disorders
- cushing’s disease
Using this drug over an extended period of time can lead to life-threatening hypothalamic-pituitary-adrenal suppression (HPA)! The risk of this adverse effect increases if this drug is rapidly discontinued. Therefore, it is very important to gradually reduce the dose before stopping prednisone completely.
For example, if you have been taking 5 mg of prednisone daily, you first need to reduce the dose to 2.5 mg per day, which should be used for about one week, and then the dose should be reduced back to 1.25 Mg per day and is used for a further week and then you can finally stop using this medication. Your doctor will explain how to exclude prednisone.
Keep in mind that Prednisone works as an immunosuppressive drug, which means it will weaken your immune system significantly. Because of this, it will be difficult for your body to fight against infections caused by bacteria, viruses, parasites and other microorganisms. If you notice signs of infection while taking this medication, tell your doctor immediately.
Pregnancy and lactation
Prednisone may cause intrauterine growth retardation and cleft palate, and its use during pregnancy is recommended only in situations where the benefits to the mother outweigh the risks to the fetus. There have been reports of hypoadrenalism (reduced levels of adrenaline in the blood) in newborns, but the symptoms disappear quickly without complications. There have been reports of cataracts in newborns whose mothers took this drug during pregnancy.
Because it is excreted in breast milk at concentrations that correspond to 5-25% of the maternal dose, breastfeeding should be avoided.
The dose ranges from 5 to 60 mg per day and depends mainly on the disease and its severity.
The use of this medication in children can delay its growth and development, therefore the use of Prednisone in patients under 18 years should be limited to the shortest possible time. In order to minimize the risk of growth and developmental delay in children Prednisone is often taken once every other day.
It is very important that you take Prednisone tablets regularly. Never stop taking this medication without consulting your doctor.